Pre-prints

Hasselluhn MC, Decker-Farrell AR, Vlahos L, Thomas DH, Curiel-Garcia A, Maurer HC, Wasko UN, Tomassoni L, Sastra SA, Palermo CF, Dalton TC, Ma A, Li F, Tolosa EJ, Hibshoosh H, Muir A, Fernandez-Zapico ME, Califano A, Olive KP (2023). Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression. bioRxiv.

Abbot KL, Ali A, Casalena D, Do BT, Ferreria R, Cheah JH, Soule CK, Deik A, Kunchok T, Schmidt DR, Renner S, Honeder SE, Wu M, Chan SH, Tseyang T, Greaves D, Hsu PP, Ng CW, Zhang CJ, Farsidjani A, Gramatikov IMT, Matheson NJ, Lewis CA, Clish CB, Rees MG, Roth JA, Griner LM, Muir A, Auld DS, Vander Heiden MG (2023). Screening in serum-derived medium reveals differential response to compounds targeting metabolism. bioRxiv.

Yesilkanal AE, Yu A, Thakur A, Wang F, Wu X, Muir A, He X, Spitz F, Yang L (2023). HYENA detects non-coding genes activated by distal enhancers in cancer. bioRxiv.

Apiz Saab JJ, Dzierozynski LD, Jonker PB, Zhu Z, Chen RN, Oh M, Sheehan C, Macleod KF, Weber CR, Muir A (2022). Pancreatic tumors activate arginine biosynthesis to adapt to myeloid-driven amino acid stress. bioRxiv.

Francescone R, Vendramini-Costa DB, Franco-Barraza J, Wagner J, Muir A, Gabitova L, Pazina T, Luong T, Shah N, Rollins D, Gupta S, Roshan T, Restifo D, Lau A, Zhou Y, Cai KQ, Hensley H, Nicolas E, Kruger W, Devarajan K, Balachandran S, El-Deiry WS, Vander Heiden MG, Campbell KS, Astsaturov I, Cukierman E (2018) NetrinG1/NGL-1 Axis promotes pancreatic tumorigenesis through cancer associated fibroblast derived nutritional supply and immunosuppression. bioRxiv.

Published papers

Nwosu ZC, Ward MH, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar RE, Andren A, Apiz-Saab JJ, Tolstyka Z, Brown K, Lee H-J, Dzierozynski LD, He X, PS H, Ugras J, Nyamundanda G, Zhang L, Halbrook CJ, Carpenter CJ, Shi J, Shriver LP, Patti GJ, Muir A, di Magliano MP, Sadanandam A, Lyssiotis CA (2023). Uridine-derived ribose fuels glucose-restricted pancreatic cancer. Pubmed.

Sullivan MR, McGowen K, Liu Q, Akusobi C, Young DC, Mayfield JA, Raman S, Wolf ID, Moody DB, Aldrich CC, Muir A, Rubin EJ (2023). Biotin-dependent cell envelope remodelling is required for Mycobacterium abscessus survival in lung infection. Pubmed.

Sela Y, Li J, Maheswaran S, Norgard RJ, Yuan S, Hubbi ME, Doepner M, Xu JP, Ho ES, Mesaros C, Sheehan C, Croley G, Muir A, Blair IA, Ophir S, Dang CV, Stanger BZ (2022). Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer. Pubmed.

Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiera A, Cohen AS, Ali A, Do BT, Lewis CA, Muir A, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O’Neil RT, Wilson MT, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK (2021). Cell-programmed nutrient partitioning in the tumor microenvironment. Pubmed.

Badeaux M, Rolig A, Agnello G, Enzler D, Kasiewicz M, Priddy L, Wiggins J, Muir A, Sullivan M, Van Cleef J, Daige C, Vander Heiden M, Rajamanickam V, Wooldridge J, Redmond W, Rowlinson S (2020). Arginase therapy combines effectively with checkpoint blockade or agonist anti-OX40 immunotherapy to control tumor growth. Pubmed.

Francescone R, Vendramini-Costa DB, Franco-Barraza J, Wagner J, Muir A, Gabitova L, Pazina T, Luong T, Shah N, Rollins D, Gupta S, Roshan T, Restifo D, Lau A, Zhou Y, Cai KQ, Hensley H, Nicolas E, Kruger W, Devarajan K, Balachandran S, El-Deiry WS, Vander Heiden MG, Campbell KS, Astsaturov I, Cukierman E (2020). Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblast driven nutritional support and immunosuppression. Pubmed.

Romero R, Sanchez-Rivera FJ, Peter MK, Mercer KL, Bhutkar A, Muir A, Gonzalez Robles TJ, Rodriguez SL, Liao LZ, Ng SR, Li L, Colon CI, Naranjo S, Beytagh MC, Lewis CA, Hsu PP, Bronson RT, Vander Heiden MG, Jacks T (2020) Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1. Pubmed.

Sullivan MR, Lewis CA, Muir A (2019) Isolation and Quantification of Metabolite Levels in Murine Tumor Interstitial Fluid by LC/MS. Pubmed.

Sullivan MR, Danai LV, Lewis CA, Chan SH, Gui DY, Kunchok T, Dennstedt EA, Vander Heiden MG, Muir A (2019) Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability. Pubmed.

Sullivan MR, Mattaini KR, Dennestedt EA , Nguyen AA, Sivanand S, Reilly MF, Meeth K, Muir A, Darnell AM, Bosenberg MW, Lewis CA, Vander Heiden MG (2019) Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting. Pubmed.

Danai LV, Babic A, Rosenthal MH, Dennestedt E, Muir A, Lien EC, Mayers JR, Tai K, Lau AN, Jones-Sali P, Prado CM, Petersen GM, Takahashi N, Sugimoto M, Yeh JJ, Lopez N, Bardessy N, Castillo CF, Liss AS, Koong AC, Bui J, Yuan C, Welch MW, Brais LK, Kulke MH, Dennis C, Clish CB, Wolpin BM, Vander Heiden MG (2018) Altered exocrine function can drive adipose wasting in early pancreatic cancer. Pubmed.

Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou A-M, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T (2017) Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. Pubmed.

Muir A, Danai LV, Gui DY, Waingarten CY, Lewis CA, Vander Heiden MG (2017) Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition. Pubmed.

Mayers, JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG (2016) Tissue-of-origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Pubmed.

Reviews

Muir A, Danai LV, Vander Heiden MG (2018) Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies. Pubmed.

Muir A, Vander Heiden MG (2018) The nutrient environment affects therapy. Pubmed.