new collaborative paper with delgoffe lab at Pitt on metabolites in the microenvironment of cancers that limit anti-tumor immunity

Congratulations to everyone from both labs on the exciting discovery that phosphoethanolamine, a metabolite not previously implicated in immunity, is enriched in tumors and suppresses T cell function and immunotherapy. Lot of exciting work to come to leverage this finding for new methods to improve immunotherapies. Check out the paper, the News and Views, and coverage from the UChicago Cancer Center.

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guillaume published new review on identifying metabolic limitations in tumors

Guillaume in the team published a new review on everything that we have learned about the nutrients that limit cancer cells in the tumor microenvironment in the last few years: https://www.science.org/doi/10.1126/sciadv.adq7305. Includes a fantastic table bringing together all the nutrient concentrations that we could find that have been measured in the tumor microenvironment.

Big picture, we think these hard numbers are going to be really important for folks studying tumor metabolism to identify metabolic pathways that can be targeted with a wide enough therapeutic window to make it to the clinic.

Congrats Guillaume and hope this is a useful resource for everyone.

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